CONE Centre for Organic and Nanohybrid Electronics

We are happy to share our new publication on the development of biosensors, which has been just published in Advanced Materials Interfaces.

Procalcitonin (PCT) serves as a valuable yet challenging biomarker for bacterial infections, with conventional detection methods constrained by prolonged assay durations. Electrochemical techniques provide a faster and more straightforward alternative, though they face challenges such as electrode fouling and limited sensitivity and selectivity. To address these issues, we developed a sensor using highly conductive Ti3C2Tx MXene combined with poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate), serving as an ideal microenvironment for the direct immobilization of PCT antibody, with a bovine serum albumin coating to provide antifouling activity. The sensor shows promise as a rapid, simple tool for diagnosing bacterial infections or sepsis, enabling timely diagnosis and improved patient outcomes.

Electrochemically Engineered PEDOT:PSS/MXene Composite Electrode for the Label-Free Procalcitonin Detection
Angelika Banaś, Roman Turczyn, Maciej Krzywiecki, Izabela Matuła, Sara Shakibania, Katarzyna Krukiewicz, Deivasigamani Ranjith Kumar