Prevention of brain scarring during cranial reconstruction through a bioactive polymer coating
Although cranioplasty is a long-established surgical procedure used to repair or reshape skull defects, it is not devoid of side effects arising from the formation of a scar tissue between dura, implant, and subcutaneous tissue. To minimize these complications, we developed a bioactive coating comprising poly(vinyl alcohol) electrospun fibers loaded with a polyanhydride based on betulin disuccinate and a tricarboxylic derivative of poly(ethylene glycol), suitable for the modification of the surface of titanium alloys. By integrating biocompatibility, modulated adhesiveness, and mechanical resilience, PVA/PEG-DBB coating presents a promising approach for enhancing cranioplasty outcomes and minimizing adhesion-related complications.
Interested in details? Check our recent paper:
Prevention of brain scarring during cranial reconstruction through a bioactive polymer coating
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