Engineering gold biointerfaces with mixed short-chain thiols
Self-assembled monolayers (SAMs) provide a powerful approach for engineering surface properties at the molecular level, widely utilized in biosensing, catalysis, and biomedical applications. Thiol-based SAMs, due to their strong gold-binding affinity and customizable functional groups, are particularly suited for modifying surfaces to influence cell-surface interactions. In our latest publication, we demonstrate that SAMs composed of mixed 2-thiophenethiol and 2-mercaptoethanol significantly influence the electrochemical, morphological, and biological performance of gold-coated neural interfaces, providing an optimal balance for neural applications, supporting neurite outgrowth, facilitating neural branching, while controlling astrocytic reactivity.
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Engineering gold biointerfaces with mixed short-chain thiols: Electrochemical and cellular studies
Colloids and Surfaces B: Biointerfaces, Volume 258, February 2026, 115230
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