New European Project MIRAMARE
We are delighted to announce that our Department has become a partner in the prestigious European project MIRAMARE, carried out under the EURATOM/PIANOFORTE funding program. The full title of the project is: Mechanisms of the Inversed Relationship Between Menarche Age and Radiation-Induced Breast and Endometrial Cancer. This initiative is funded by the European Commission.
MIRAMARE is a collaborative effort involving leading scientific institutions:
- Stockholm University (Sweden),
- French Alternative Energies and Atomic Energy Commission (CEA) (France),
- University of Campania (UCampania) (Italy),
- Silesian University of Technology (SUT) (Poland).
Objectives and Scope of Research
The MIRAMARE project aims to elucidate the mechanisms behind the clinically observed relationship between the age of menarche and the risk of radiation-induced breast and endometrial cancers. The research will be conducted using cell models and validated with data. Scientists will investigate the impact of obesity-related hormones (e.g., leptin) and sex hormones (estrogen and progesterone) on irradiated cells. Two irradiation scenarios will be analyzed: a single exposure to a high dose and chronic exposure to low doses. The study will examine changes at the levels of the epigenome, genome, cellular aging, immune response, and stem cell properties.
Expected Outcomes
Through the use of advanced bioinformatics techniques and artificial intelligence, the project aims to provide new insights into the influence of obesity and menarche age on the risk of radiation-induced cancers. The findings could contribute to more effective cancer prevention strategies for women and advance the field of radiological protection.
