Bioelectrochemistry Group
Bioelectrochemistry Group
Bioelectrochemistry Group
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Project details
Project title: The key role of electrode nanostructuring to achieve ultrasensitive detection of cancer biomarkers
Period: 2.04.2024–01.04.2028
Budget: 2 599 820 PLN
Principal investigator
Prof. Serge Cosnier
Centre for Organic and Nanohybrid Electronics, Silesian University of Technology
Konarskiego 22B, Room no. 307, 44-100 Gliwice, Poland
Project team
Grant agency and contract number
This research is funded by National Science Centre, Poland [Opus 2023/49/B/ST4/02942].
Project description
Cancer diseases are one of the leading causes of mortality within world population today. The incidence of thyroid cancer, particularly, is observed to rise worldwide. The challenge in treatment of thyroid cancer patients is to balance the therapeutic approach to avoid over-treatment of patients with a lower risk of disease, and to provide a more aggressive treatment to the ones with a more advanced disease. Therefore, the accurate diagnosis of the severity of thyroid cancer plays a central role in the management of this disease.
The goal of this project is to develop a simple and fast electrochemical platform for the ultrasensitive detection of a thyroid cancer biomarker (thyroglobulin), based on polymer nanoparticles functionalized with antibodies and a 3D nanostructured electrode. The resulting system should be applicable in a design of a lateral flow immunoassay system. The modus operandi of such a system would be based on the reaction of nanoparticles deposited on the support of the lateral flow system with the sample containing the biomarker. Next steps involve the migration of nanoparticles towards the electrode surface modified by antibodies, and their immobilization onto the modified electrode by immunoreaction, resulting in anchoring that will modify the intensity of the electrochemical signals. This original concept can be successfully extended to different types of antigens and therefore to various types of cancer or even to DNA sensors and aptasensors, thus opening the fields of application from biomedical to the environment.
Results of the project
- Publications
- Conferences
EuroScience Open Forum, 12-15 VI 2024, Katowice (Poland). Saad Muhammad, Krukiewicz Katarzyna, Cosnier Serge: PERMEABILITY OF CARBON NANOTUBE-BASED BUCKYPAPER AND ITS EFFECTS ON BIOFUEL CELL DEVELOPMENT (poster)
11th International Workshop on Biosensors, 3-5 X 2024, Marrakesh (Morocco), K. Krukiewicz, A. Banaś, R. Turczyn, J. Kappen, D. R. Kumar. NANOSTRUCTURIZED ELECTRODES FOR ULTRASENSITIVE DETECTION OF BIOMARKERS (oral communication)
11th International Workshop on Biosensors, 3-5 X 2024, Marrakesh (Morocco), S. Cosnier, K. Krukiewicz, M. Saad, M. Lapkowski. BIOELECTROCHEMICAL DEVICES BASED ON BUCKYPAPERS (oral communication)
35th Anniversary World Congress on Biosensors, 19-22 V 2025, Lisbon, Portugal, Sasan Radfar, Katarzyna Krukiewicz, Serge Cosnier, All-in-one ECL platform: A self-boosting nanoarchitecture for ultra-stable emission (poster presentation)
35th Anniversary World Congress on Biosensors, 19-22 V 2025, Lisbon, Portugal, Muhammad Saad, Krzysztof Karoń, Yannig Nedellec, Wojciech Pudło, Katarzyna Krukiewicz, Serge Cosnier, Optimization of Bucky Papers in Terms of Flexibility, and Permeability for the Design of Microcavity-Based Biofuel Cells (poster presentation)
InterNanoPoland, 8-9 X 2025, Katowice, Poland, Muhammad Saad, Krzysztof Karoń, Yannig Nedellec, Wojciech Pudło, Katarzyna Krukiewicz, Fabien Giroud, Serge Cosnier, Buckypaper Based Microcavity Bio Electrodes: Balancing Substrate Diffusion and Enzymes Retention for Biofuel Cells (poster presentation)
5th European Biosensor Symposium, 26-29 X 2025, Tarragona, Spain, Muhammad Saad, Krzysztof Karoń, Yannig Nedellec, Wojciech Pudło, Katarzyna Krukiewicz, Fabien Giroud, Serge Cosnier, Enhancing Bioelectrocatalytic Electrode Performance through Permeability Optimization of Buckypapers for Microcavity-Based Biofuel Cells (poster presentation)
Gliwice Scientific Meetings, 20-21 XI 2025, Gliwice, Szymon Smołka, Serge Cosnier, Katarzyna Krukiewicz, Targeting thyroid cancer biomarkers: The key role of microstructurring for best detection (poster presentation)
Young Science Beyond Borders, 23-24 X 2025, Online, Szymon Smołka, Serge Cosnier, Katarzyna Krukiewicz, Microstructurization of poly(3,4-ethylenedioxytiophene) films for biosensing applications (oral presentation, best presentation award)
- Popularization of science
