Microfluidics is a modern technology that can replace traditional methods of conducting biological experiments by offering precise control over fluid flow and high throughput. In recent years, research has highlighted the immense potential of microfluidics in advancing biological studies and medical diagnostics. To best replicate in vivo conditions, the project involves cultivating cells in micro-incubation chambers filled with hydrogel. Thanks to their structure, hydrogels resemble the native extracellular matrix, which enables effective imitation of the cells' natural growth environment. The use of specially designed microchambers combined with hydrogel with unique properties allows the creation of an innovative platform for studying cell populations. This solution enables precise assessment of cellular responses to specific chemicals or drugs. A numerical diffusion model of substances in the medium will be used for virtual testing of the designed microfluidic systems, allowing optimization of the solutions before they are put into production. The proposed microfluidic system opens new research possibilities, allowing for a precise analysis of cell behavior under experimental conditions that are not achievable with conventional macroscopic tools.
The “Innovative system for testing chemical compounds (especially drugs) on human and animal cells based on microfluidics” project is carried out within the Proof of Concept (PoC FENG) programme of the Foundation for Polish Science co-financed by the European Union under the European Funds for Smart Economy 2021-2027 (FENG).
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